Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment

Žiga Tkalec (1, 2) , Jean-Philippe Antignac (3) , Nicole Bandow (4) , Frederic Béen (5) , Lidia Belova (6) , Jos Bessems (7) , Bruno Le Bizec (3) , Werner Brack (8, 9) , Germán Cano-Sancho (3) , Jade Chaker (10, 11, 12) , Adrian Covaci (6) , Nicolas Creusot (13) , Arthur David (10) , Laurent Debrauwer (14, 15) , Gaud Dervilly (3) , Radu Corneliu Duca (16) , Valérie Fessard (17) , Joan O. Grimalt (18) , Thierry Guérin (19) , Baninia Habchi (20) , Helge Hecht (1) , Juliane Hollender (21) , Emilien Jamin (14) , Jana Klánová (1) , Tina Kosjek (2) , Martin Krauss (9) , Marja Lamoree (5) , Gwenaëlle Lavison-Bompard (19) , Jeroen Meijer (5) , Ruth Moeller (22) , Hans Mol (23) , Sophie Mompelat (17) , An van Nieuwenhuyse (23) , Herbert Oberacher (24) , Julien Parinet (19) , Christof van Poucke (25) , Robert Roškar (26) , Anne Togola (27) , Jurij Trontelj (26) , Elliott J. Price (1)

1 MUNI - Masaryk University [Brno]
2 IJS - Jozef Stefan Institute [Ljubljana]
3 LABERCA - Laboratoire d'étude des Résidus et Contaminants dans les Aliments
4 UBA - German Federal Environmental Agency / Umweltbundesamt
5 VU - Vrije Universiteit Amsterdam [Amsterdam]
6 UA - University of Antwerp
7 VITO - Vlaamse Instelling voor Technologisch Onderzoek [Mol]
8 Goethe University Frankfurt
9 UFZ - Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research
10 Irset - Institut de recherche en santé, environnement et travail
11 EHESP - École des Hautes Études en Santé Publique [EHESP]
12 LERES - Laboratoire d'étude et de recherche en environnement et santé
13 UR EABX - Ecosystèmes aquatiques et changements globaux
14 ToxAlim - ToxAlim
15 E20 - Metatoul AXIOM
16 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
17 Laboratoire de Fougères - ANSES
18 IDAEA - Institute of Environmental Assessment and Water Research
19 ANSES - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail
20 INRS ( Vandoeuvre lès Nancy) - Institut national de recherche et de sécurité (Vandoeuvre lès Nancy)
21 IBP - Institute of Biogeochemistry and Pollutant Dynamics [ETH Zürich]
22 LNS - Laboratoire National de Santé [Luxembourg]
23 WFSR - Wageningen Food Safety Research
24 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
25 ILVO - Research Institute for Agricultural, Fisheries and Food
26 University of Ljubljana
27 BRGM - Bureau de Recherches Géologiques et Minières

The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent adverse impacts on human and environmental health associated with hazardous chemicals. Surveillance of chemicals of known, emerging, or potential future concern, entering the environment-food-human continuum is needed to document the reality of risks posed by chemicals on ecosystem and human health from a one health perspective, feed into early warning systems and support public policies for exposure mitigation provisions and safe and sustainable by design strategies. The use of less-conventional sampling strategies and integration of full-scan, high-resolution mass spectrometry and effect-directed analysis in environmental and human monitoring programmes have the potential to enhance the screening and identification of a wider range of chemicals of known, emerging or potential future concern. Here, we outline the key needs and recommendations identified within the European Partnership for Assessment of Risks from Chemicals (PARC) project for leveraging these innovative methodologies to support the development of next-generation chemical risk assessment.

Mots clés: High-resolution mass spectrometry; Effect-based methods; Sampling strategies; Chemical exposure; Chemical risk assessment; Effect-directed analysis

Domaines: Sciences du Vivant [q-bio]

Žiga Tkalec, Jean-Philippe Antignac, Nicole Bandow, Frederic Béen, Lidia Belova, et al.. Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment. Environment International, 2024, Environment International, 186, pp.108585. ⟨10.1016/j.envint.2024.108585⟩. ⟨hal-04513053⟩