Influence of the morphogranulometry and hydrophobicity of talc on its antisticking power in the production of tablets

P. Leterme (1, 2) , A. Gayot (1, 2) , G. Finet (1, 2) , Mohamed Bizi (3) , M.P. Flament (1, 2)

1 Faculté des Sciences Pharmaceutiques et Biologiques
2 Laboratoire de pharmacotechnie Industrielle - EJ 2401
3 BRGM - Bureau de Recherches Géologiques et Minières (BRGM)

Antisticking power varies according to the talc considered. It is difficult to define the physical properties of talc implicated in its antisticking power. In this work, different talcs were characterized and an evaluation made of their performance in reducing sticking in tablet manufacturing. Determination of the specific surface area was made by permeametry, morphogranulometric analysis by laser diffractometry using a method, which made it possible to assess the mean thickness of talc particles, and measurement of water absorption kinetics was taken to assess hydrophobicity. The relationship between the characteristics of talcs and their antisticking power was then considered. There is a correlation between the particle size of talc and surface hydrophobicity. The detaching force of tablets appears to be dependent on the basal dimension of talc.

Mots clés: Talc; Morphogranulometry; Hydrophobicity; Antisticking power; Functionality assay

Domaines: Sciences de la Terre

P. Leterme, A. Gayot, G. Finet, Mohamed Bizi, M.P. Flament. Influence of the morphogranulometry and hydrophobicity of talc on its antisticking power in the production of tablets. International Journal of Pharmaceutics, 2005, 289 (1-2), pp.109-115. ⟨10.1016/j.ijpharm.2004.10.023⟩. ⟨hal-03759018⟩