Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

COMPRENDO: Focus and Approach

Abstract : Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife. Given the complexity of endocrine systems, there are many ways in which endocrine-disrupting chemicals (EDCs) can affect the body’s signaling system, and this makes unraveling the mechanisms of action of these chemicals difficult. A major concern is that some of these EDCs appear to be biologically active at extremely low concentrations. There is growing evidence to indicate that the guiding principle of traditional toxicology that “the dose makes the poison” may not always be the case because some EDCs do not induce the classical dose–response relationships. The European Union project COMPRENDO (Comparative Research on Endocrine Disrupters—Phylogenetic Approach and Common Principles focussing on Androgenic/Antiandrogenic Compounds) therefore aims to develop an understanding of potential health problems posed by androgenic and antiandrogenic compounds (AACs) to wildlife and humans by focusing on the commonalities and differences in responses to AACs across the animal kingdom (from invertebrates to vertebrates).
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-brgm.archives-ouvertes.fr/hal-03753417
Contributeur : Frédérique COUFFIGNAL Connectez-vous pour contacter le contributeur
Soumis le : jeudi 18 août 2022 - 11:57:28
Dernière modification le : jeudi 18 août 2022 - 11:58:55

Fichier

ehp.8060.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

Ulrike Schulte-Oehlmann, Triantafyllos Albanis, Axel Allera, Jean Bachmann, Pia Berntsson, et al.. COMPRENDO: Focus and Approach. Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2006, 114 (Suppl 1), pp.98 - 100. ⟨10.1289/ehp.8060⟩. ⟨hal-03753417⟩

Partager

Métriques

Consultations de la notice

23

Téléchargements de fichiers

1